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That is painful to hear, but nevertheless it is true. The next layer down from the top is the dermis. This is the layer where wrinkles develop. The dermis consists of living cells, and they are responsible for the structure, integrity and elasticity of the skin. Here collagen is regenerated whilst existing collagen is broken down in the monthly cellular cycle. The production of collagen slows with age and factors like smoking, sun exposure, stress and inadequate nutrition. Other skin nutrients proheptazine elastin and hyaluronic acid are found here.
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